rpoB - ARO:3003288-NP_312937.1
Model based on:
Entry features
| GENE | rpoB | |
|---|---|---|
| DESCRIPTION | RNA polymerase subunit beta | |
| ORGANISM | Escherichia coli O157:H7 str. Sakai | |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;Enterobacteriaceae; Escherichia. | |
| UNIPROT | P0A8V4 | |
| NCBI | NP_312937.1 | |
| ARO term | ARO:3003288 | |
| Template | 4ljz I | |
| RESISTANCE | peptide; rifabutin; rifampin; rifamycin; rifapentine; rifaximin |
Cross-references
| STRING | 155864.Z5560 | |
|---|---|---|
| REFSEQ | NP_312937.1; NC_002695.1; WP_000263098.1; NZ_NOKN01000002.1 | |
| PFAM | PF00562 - RNA_pol_Rpb2_6; PF04560 - RNA_pol_Rpb2_7; PF04561 - RNA_pol_Rpb2_2; PF04563 - RNA_pol_Rpb2_1; PF04565 - RNA_pol_Rpb2_3; PF10385 - RNA_pol_Rpb2_45 | |
| PATRIC | fig|386585.9.peg.5134 | |
| KEGG | ece:Z5560; ecs:ECs4910 | |
| EMBL | AE005174; AAG59183.1; BA000007; BAB38333.1 | |
| EC | 2.7.7.6 | |
| Catalytic activity | Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); ECO:0000255| HAMAP-Rule:MF_01321 | |
| MINT | P0A8V4 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003899 | F:DNA-directed 5'-3' RNA polymerase activity | IEA | |
| GO:0032549 | F:ribonucleoside binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006351 | P:transcription, DNA-templated | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| H526Y | resistant | PMID:3050121 | 524 |
| L533P | resistant | PMID:3050121 | 531 |
| P564L | resistant | PMID:3050121 | 562 |
| Q513L | resistant | PMID:3050121 | 511 |
| Q513P | resistant | PMID:3050121 | 511 |
| R529C | resistant | PMID:3050121 | 527 |
| R529S | resistant | PMID:3050121 | 527 |
| R687H | resistant | PMID:3050121 | 685 |
| S531F | resistant | PMID:3050121 | 529 |
| T563P | resistant | PMID:3050121 | 561 |
| V146F | resistant | PMID:3050121 | 144 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| H526Y | 526 |
| L533P | 533 |
| P564L | 564 |
| Q513L | 513 |
| Q513P | 513 |
| R529C | 529 |
| R529S | 529 |
| R687H | 687 |
| S531F | 531 |
| T563P | 563 |
| V146F | 146 |