cls - ARO:3003074-YP_500802.1
No structure available
Entry features
| GENE | cls |
|---|---|
| ORGANISM | Staphylococcus aureus subsp. aureus NCTC 8325 |
| TAXONOMY | Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;Staphylococcus. |
| UNIPROT | Q2FWG8 |
| NCBI | YP_500802.1 |
| ARO term | ARO:3003074 |
| RESISTANCE | daptomycin; peptide |
Cross-references
| STRING | 93061.SAOUHSC_02323 | |
|---|---|---|
| REFSEQ | WP_000571549.1; NZ_LS483365.1; YP_500802.1; NC_007795.1 | |
| PFAM | PF13091 - PLDc_2; PF13396 - PLDc_N | |
| PATRIC | fig|93061.5.peg.2106 | |
| KEGG | sao:SAOUHSC_02323 | |
| EMBL | CP000253; ABD31357.1 | |
| BioCyc/EcoCyc/MetaCyc | SAUR93061:G1G5Y-2195-MONOMER | |
| EC | 2.7.8.- | |
| Catalytic activity | 2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn- glycerol) = a cardiolipin + glycerol; ECO:0000256| HAMAP- Rule:MF_01916 ; ECO:0000256| SAAS:SAAS01063315 | |
| Active site | 234 234 {ECO:0000256|HAMAP-Rule:MF_01916}; 236 236 {ECO:0000256|HAMAP-Rule:MF_01916}; 241 241 {ECO:0000256|HAMAP-Rule:MF_01916}; 412 412 {ECO:0000256|HAMAP-Rule:MF_01916}; 414 414 {ECO:0000256|HAMAP-Rule:MF_01916}; 419 419 {ECO:0000256|HAMAP-Rule:MF_01916} |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0008808 | F:cardiolipin synthase activity | IBA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0032049 | P:cardiolipin biosynthetic process | IBA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005886 | C:plasma membrane | IEA | |
| GO:0016020 | C:membrane | IBA | |
| GO:0016021 | C:integral component of membrane | IEA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| A23V | resistant | PMID:22238576 |
| F60S | resistant | PMID:22238576 |
| L52F | resistant | PMID:22238576 |
| T33N | resistant | PMID:22238576 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| A23V | 23 |
| F60S | 60 |
| L52F | 52 |
| T33N | 33 |