PBP2b - ARO:3003042-NP_359110.1
Structure
Entry features
| GENE | PBP2b |
|---|---|
| ORGANISM | Streptococcus pneumoniae R6 |
| TAXONOMY | Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;Streptococcus. |
| UNIPROT | P0A3M6 |
| NCBI | NP_359110.1 |
| ARO term | ARO:3003042 |
| RESISTANCE | amoxicillin; carbapenem; cephalosporin; cephamycin; monobactam; penam |
Cross-references
| STRING | 171101.spr1517 | |
|---|---|---|
| REFSEQ | NP_359110.1; NC_003098.1 | |
| PFAM | PF00905 - Transpeptidase; PF03717 - PBP_dimer | |
| PATRIC | fig|171101.6.peg.1637 | |
| KEGG | spr:spr1517 | |
| EMBL | AE007317; AAL00321.1; ALT_INIT; X13137; CAA31527.1; X16022; CAA34154.1 | |
| Drugbank | DB00319 - Piperacillin; DB00415 - Ampicillin; DB00456 - Cefalotin; DB00485 - Dicloxacillin; DB00493 - Cefotaxime; DB00567 - Cephalexin; DB00607 - Nafcillin; DB00713 - Oxacillin; DB00739 - Hetacillin; DB01066 - Cefditoren; DB01140 - Cefadroxil; DB01163 - Amdinocillin; DB01212 - Ceftriaxone; DB01331 - Cefoxitin; DB01603 - Meticillin; DB03313 - Cephalosporin C; DB08795 - Azidocillin | |
| Active site | 386 386 Acyl-ester intermediate |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0008658 | F:penicillin binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0008360 | P:regulation of cell shape | IEA | |
| GO:0009252 | P:peptidoglycan biosynthetic process | IEA | |
| GO:0046677 | P:response to antibiotic | IEA | |
| GO:0071555 | P:cell wall organization | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005886 | C:plasma membrane | IEA | |
| GO:0016021 | C:integral component of membrane | IEA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| E475G | resistant | PMID:18394970 |
| T445A | resistant | PMID:18394970 |
| T488A | resistant | PMID:18394970 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| E475G | 475 |
| T445A | 445 |
| T488A | 488 |