mexR - ARO:3000506-NP_249115.1
Structure
Entry features
| GENE | mexR |
|---|---|
| ORGANISM | Pseudomonas aeruginosa PAO1 |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;Pseudomonadaceae; Pseudomonas. |
| UNIPROT | P52003 |
| NCBI | NP_249115.1 |
| ARO term | ARO:3000506 |
| RESISTANCE | aminocoumarin; carbapenem; cephalosporin; cephamycin; diaminopyrimidine; fluoroquinolone; macrolide; monobactam; penam; penem; peptide; phenicol; sulfonamide; tetracycline |
Cross-references
| STRING | 208964.PA0424 | |
|---|---|---|
| REFSEQ | NP_249115.1; NC_002516.2; WP_003114897.1 | |
| PFAM | PF01047 - MarR | |
| PATRIC | fig|208964.12.peg.446 | |
| KEGG | pae:PA0424 | |
| EMBL | AE004091; AAG03813.1; AY190292; AAO40255.1; AY190293; AAO40256.1; AY190294; AAO40257.1; AY190295; AAO40258.1; AY899299; AAW82614.1; AY899300; AAW82615.1; AY899301; AAW82616.1; U23763; AAA69479.1 | |
| BioCyc/EcoCyc/MetaCyc | PAER208964:G1FZ6-428-MONOMER | |
| INTACT | P52003 | |
| MINT | P52003 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0000976 | F:transcription regulatory region sequence-specific DNA binding | IDA | |
| GO:0001217 | F:bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding | IDA | |
| GO:0042802 | F:identical protein binding | IPI | |
| GO:0044212 | F:transcription regulatory region DNA binding | IDA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006351 | P:transcription, DNA-templated | IEA | |
| GO:0034763 | P:negative regulation of transmembrane transport | IMP | |
| GO:0045892 | P:negative regulation of transcription, DNA-templated | IMP | |
| GO:0050709 | P:negative regulation of protein secretion | IMP | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0032993 | C:protein-DNA complex | IDA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| H107P | resistant | PMID:14526032 |
| I46N | resistant | PMID:14526032 |
| I72N | resistant | PMID:14526032 |
| L45P | resistant | PMID:14526032 |
| L57P | resistant | PMID:14526032 |
| L57R | resistant | PMID:14526032 |
| L75P | resistant | PMID:14526032 |
| L75R | resistant | PMID:14526032 |
| N53D | resistant | PMID:12727072 |
| R83C | resistant | PMID:14526032 |
| R91C | resistant | PMID:14526032 |
| R91H | resistant | PMID:14526032 |
| T69I | resistant | PMID:14526032 |
Sequence
Multiple sequence alignment Not Available
MSA Mutation Not Available